β-lactamase reporter system for selecting high-producing yeast clones

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Beta-lactamase reporter system for selecting high-producing yeast clones.

In modern production of protein biopharmaceuticals, a good screening and selection method of high-producing clones can dramatically influence the whole production process and lead to lower production costs. We have created a rapid, simple, and inexpensive method for selecting high-producing clones in the yeast Pichia pastoris that is based on the beta-lactamase reporter system. By integrating t...

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ژورنال

عنوان ژورنال: BioTechniques

سال: 2008

ISSN: 0736-6205,1940-9818

DOI: 10.2144/000112730